What are Orthobiologics?

Orthobiologics involves the use of naturally occurring biologic substances, like scaffolds, cells or proteins that your physician may use to help optimize healing for injuries to bone, cartilage, tendons or ligaments.  Orthobiologic products may be derived from an array of different sources.

If the product comes directly from the patient, it is an autograft. If the product comes from donated tissue, it is an allograft. In some cases,
biologic materials may also be a combination of synthetic and biologic materials.


What are some common options of orthobiologics and which one is right for me?


Platelet rich plasma (PRP) & Bone Marrow Aspirate Concentrate (BMAC)

Used in joint arthritis, muscle tendon injury, cartilage preservation, rotator cuff repair

Platelet-Rich Plasma (PRP) is a concentration of a portion of your blood called platelets. These cells contain specialized proteins and growth factors that enhance healing and leverage the immune system in response to injury and disease.

PRP is produced by taking a small amount of your own blood during an office visit and spinning it in a centrifuge. Blood components (ex. red
blood cells, white blood cells, platelets) are separated and then injected into the location of injury or painful joint.

Bone Marrow Aspirate Concentrate, or “BMAC,” contains some stem cells, higher concentrations of white blood cells than PRP, in addition to anti-inflammatory
enzymes and growth proteins.

BMAC can be harvested from many areas of your own body, including the hip, knee, ankle or shoulder. It is concentrated in a similar manner to PRP for the treatment of your injury.

General Orthopaedics

Amniotic Tissue

Used in joint arthritis; cartilage damage or degeneration; meniscal repairs; ligament; and tendon injuries.

Mesenchymal stem cells have the advantage of becoming any cell (pluripotent) and  potentially forming into any host cell to regenerate tissue. 

This is a protective amniotic tissue and fluid that forms surrounding a baby during pregnancy. This membrane and fluid is carefully recovered and voluntarily donated after a full-term, healthy delivery (by Caesarean section).

These cells are rich in growth factors, anti-inflammatory proteins and hyaluronic acid that may aid in the healing process through reducing scar tissue formation. All fluids are serologically tested to the strictest FDA standards.

Sports Medicine Outreach Program

Cartilage & Meniscal Replacement

Many individuals sustain injuries to their meniscus and joint surface cartilage. These two parts of our knee work better together and decrease stress across the joint. A loss of either will lead to an increase in the development of traumatic arthritis.

There are multiple options to replace the damaged area with any combination of autogenous (your own) or allogenic (donor) regenerative substitutes.  Fresh cartilage can be transferred from one spot to another.

Allograft articular cartilage and meniscii can be replaced at the site of injury.  Options vary between each individual. A structured plan can be developed for each individual who suffers from persistent activity-limiting pain.

Insurance questions

While several of these treatments have been around for many years, many insurance companies still consider these treatments experimental and deny coverage. We will contact your insurance company to confirm cost on your procedure prior to scheduling. If your insurance will not cover the treatment, your provider may discuss other payment options

appointment scheduling

To schedule an appointment with Robert Dugas, MD, contact our office at (402) 488-3322.

Dr. Dugas and his team will assess you at an initial office visit to determine whether orthobiologics would be right for you.

Robert W Dugas, M.D.